《计算机应用研究》|Application Research of Computers

DNA甲基化差异模式识别方法综述

Survey of DNA differentially methylated patterns identification

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作者 赵倩,张雪,张彦,林正奎,孙野青
机构 大连海事大学 a.信息科学技术学院;b.环境科学与工程学院,辽宁 大连 116026
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文章编号 1001-3695(2021)05-001-1281-06
DOI 10.19734/j.issn.1001-3695.2020.05.0157
摘要 目前,微阵列芯片技术和重亚硫酸氢盐测序技术贡献了大量DNA甲基化实验数据,基于不同数据产生了众多识别差异甲基化位点及差异甲基化区域的方法。为了对DNA甲基化差异模式识别方法进行梳理,首先介绍了DNA甲基化研究现状,包括DNA甲基化检测方法和数据类型,以及两种DNA甲基化差异模式;接着详细阐述了芯片数据的差异甲基化位点和差异甲基化区域的识别方法,并介绍了基于八种不同算法原理的测序数据的差异甲基化模式识别方法,重点阐述了各种算法的原理、应用场景以及算法的优点和局限性;最后指出了现阶段DNA甲基化差异模式识别存在的问题和未来可能的发展趋势。
关键词 DNA甲基化; 甲基化差异模式; 差异甲基化位点; 差异甲基化区域; 识别
基金项目 国家自然科学基金资助项目(31770918)
中国科学院空间科学战略性先导科技专项(XDA04020202-12,XDA04020412)
本文URL http://www.arocmag.com/article/01-2021-05-001.html
英文标题 Survey of DNA differentially methylated patterns identification
作者英文名 Zhao Qian, Zhang Xue, Zhang Yan, Lin Zhengkui, Sun Yeqing
机构英文名 a.College of Information Science & Technology,b.College of Environmental Science & Engineering,Dalian Maritime University,Dalian Liaoning 116026,China
英文摘要 At present, microarray chip technology and sodium bisulfite sequencing technology have contributed a large amount of DNA methylation data. Based on different data type, there have been many methods to identify differentially methylated locis and regions. To sort out the methods of differentially methylated pattern identification, this paper firstly introduced the research status of DNA methylation, including detection methods and data types of DNA methylation, as well as two kinds of differentially methylated patterns. Then the paper elaborated on the identification methods of differentially methylated locis and regions on the chip data, and the identification methods of differentially methylated patterns on the sequencing data based on eight different algorithm principles. This paper focused on the principles, application scenarios, advantages and limitations of these algorithms. Finally, the paper pointed out the problems of differentially methylated pattern identification and possible future development trends.
英文关键词 DNA methylation; differentially methylated pattern; differentially methylated loci; differentially methylated region; identification
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收稿日期 2020/5/15
修回日期 2020/7/4
页码 1281-1286,1293
中图分类号 TP391
文献标志码 A